不同分娩方式产妇产后血清催乳素水平、自评泌乳量及初乳中生长因子浓度的比较

Objective To compare the difference in serum prolactin levels and self-estimated milk yield and the concentrations of growth factors of human colostrum from 2d to 5d after delivery between spontaneous labor and cesarean section. Methods The serum prolactin levels were measured during 6-24 hours after parturition in the spontaneous labor and cesarean setion using chemiluminescent immunoassay, and the levels of IGF-1, EGF are tested at the same time using the technique of ABC- ELISA. Results There was a significantly lower postpartum prolactin (PRL) level in the caesarean section group (221.94 ± 90.82ng/ml) compared with spontaneous labor group (361.67±80.74ng/ml) (P<0.05). The levels of IGF-1 of the colostrum in the cesarean section group were higher significantly than those of the spontaneous group from 2d to 3d after delivery (P<0. 05) and the self-estimated milk yeld in the cesarean section group were lower significantly than spontaneous group from 2d to 3d after delivery (P<0. 05). From 4d to 5d after parturition, there was no significant difference in IGF-1 and self-estimated milk yeild between the two groups (P>0.05). Meanwhile, there was no significant difference in EGF between the two groups from 2d to5d after parturition (P>0.05). Conclusions During 6-24 h after parturition, the serum prolactin levels of normal labor group are higher than that of the cesarean section group. The growth factors in human early colosrum of cesarean section group are higher than that of the spontaneous labor group. Caesarean section is associated with significantly lower postpartum PRL and the higher IGF-1, which is related to the longer breastfeeding initiation and lower milk yield. Necessary measures including promoting the secretion of postpartum PRL such as early contact and early sucking should be taken to improve the breastfeeding.