不同粒度的羧甲基壳聚糖银噻苯咪唑复合抗菌剂的抑菌性能研究

o increase the solubility and trace its variation in antimicrobial activity after powdering process, Ag-Carboxymethyl Chitosan-thiabendazole (Ag-CMCTS-TBZ) with low concentration of Ag+ and thiabendazole (TBZ) was prepared and powdered into three agents with size distribution of 150-74μm、74-45μm and -45μm by standard sieves separating system and marked with C1, C2 and C3 respectively. Particle size analysis shows the apparent diameter of the three agents varies from 13-250 nm or so and all possess good solubility of higher than 0.4%. FT-IR and UV spectroscopy show that binding among Ag+ and TBZ to the skeleton of CMCTS changed under the powdering process and led to decreasing in antimicrobial activity. The minimum inhibitory concentration (MIC) assessment shows C1 presented the best antimicrobial activity with MICs of 400, 800mg/L to E. coli and S. aureus respectively but with poorer performance to A. niger. The antimicrobial activity of C2 is secondary to C1 and and C3 presented the worst antimicrobial performance with MICs all higher than 1000 mg/L for all microbes in test.