Changes in Anterior and Posterior Hippocampus Differentially Predict Item-Space, Item-Time, and Item-Item Memory Improvement
Changes in Anterior and Posterior Hippocampus Differentially Predict Item-Space, Item-Time, and Item-Item Memory Improvement
Abstract Relational memory requires the hippocampus, but whether distinct hippocampal mechanisms along the anterior-posterior axis are required for different types of relations is debated. We investigated the contribution of structural changes in hippocampal head, body, and tail subregions to the capacity to remember item-space, item-time, and item-item relations. Memory for each relation and volumes of hippocampal subregions were assessed longitudinally in 171 participants across 3 time points (Mage at T1= 9.45 years; Mage at T2= 10.86 years, Mage at T3=12.12 years; comprising 393 behavioral assessments and 362 structural scans). Among older children, volumetric growth in: (a) head and body predicted improvements in item-time memory, (b) head predicted improvements in item-item memory; and (c) right tail predicted improvements in item-space memory. The present research establishes that volumetric changes in hippocampal subregions differentially predict changes in different aspects of relational memory, underscoring a division of labor along the hippocampal anterior-posterior axis.
Bunge Silvia A.、Lee Joshua K.、Cohen Neal J.、Johnson Elliott G.、Ghetti Simona、Fandakova Yana
Department of Psychology, University of California||Helen Wills Neuroscience Institute, University of CaliforniaMIND Institute, University of California Davis School of Medicine||Department of Psychiatry and Behavioral Sciences, University of California Davis School of MedicineBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-ChampaignHuman Development Graduate Group, University of California||Center for Mind and Brain, University of CaliforniaCenter for Mind and Brain, University of California||Department of Psychology, University of CaliforniaCenter for Lifespan Psychology, Max Planck Institute for Human Development
神经病学、精神病学基础医学生理学
memorydevelopmenthippocampusspacetimelongitudinalvolumetricassociative
Bunge Silvia A.,Lee Joshua K.,Cohen Neal J.,Johnson Elliott G.,Ghetti Simona,Fandakova Yana.Changes in Anterior and Posterior Hippocampus Differentially Predict Item-Space, Item-Time, and Item-Item Memory Improvement[EB/OL].(2025-03-28)[2025-05-07].https://www.biorxiv.org/content/10.1101/551705.点此复制
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