染色体9p21遗传变异与中国汉族人群冠心病关系的病例对照研究及Meta-分析

Objective: To explore the association of rs2383206 and rs2383207 genetic variations in 9p21 region with coronary heart disease (CHD) in Chinese Han Population. Methods: We conducted a case-control study. Cases were CHD patients (n=580), controls were randomly selected age and sex matched normal people (n=539). General demographic data, medical history data and laboratory data were collected. Rs2383206 and rs2383207 loci were genotyped with Sequenom MassARRAY time of flight mass spectrometer (TOF); SPSS17.0 was used for result analysis. A thorough literature search about studies on the relationship between the polymorphism of rs2383206 and rs2383207 loci and CHD was performed among Chinese Biomedical Literature Database (CBM), Chinese Knowledge Internet (CNKI) and PubMed. Rev Man 5.0 software was used to perform the meta-analysis on those valid studies. Results: Smoking, waist-to-hip ratio (WHR), hypertension, diabetes mellitus, systolic blood pressure, diastolic blood pressure and total cholesterol were statistically different in two groups (P＜0.05); No significant associations between rs2383206 and CHD was observed in the study (P＞0.05), while rs2383207 was statistically different (P＜0.05), the distribution of AA genotype in the patient group (8.3%) was significantly lower than the control group (13.6%). Six studies met the inclusion criteria, including 4836 patient s and 4789 controls. Meta-analysis demonstrated disease association for rs2383206 AA genotype (OR=0.77, 95% CI 0.66-0.89), rs2383207 AA genotype (OR=0.75, 95% CI 0.61-0.92). Conclusions: Smoking, waist-to-hip ratio, hypertension, diabetes mellitus, systolic blood pressure, diastolic blood pressure and total cholesterol may be risk factors for coronary heart disease; 9p21 rs2383206 and rs2383207 loci AA genotype may be the protection genotype of CHD.