保护基对化学合成均质壳寡糖的影响

s a new physiological material, chito-oligosaccharides have a variety of biological activities such as antibacterial, antitumor and immunity-enhancing properties. Chemical synthesis of homogeneous chito-oligosaccharides is important for exploring its structure-activity relationships. Protecting groups play a significant role in oligosaccharide synthesis. The effects of different hydroxy-protecting groups (benzyl and acetylgroup) and amino-protecting groups (N-phthaloyl、N-trichloroethoxycarbonyl and N-carboxybenzyl group) on the synthesis of homogeneous chitooligosaccharides have been investigated in this work. The glycosyl donor and acceptor with similar protecting groups have been prepared rapidly for synthesis of chitotetraose. The glycosyl building blocks protected with phthaloyl group and benzyl group showed a high efficiency for chitotetraose synthesis. The results provide meaningful information for application of chemical synthesis of homogeneous chitooligosaccharides and their derivatives.