利用隐马尔科夫模型识别黄瓜MAPK基因家族及其分子进化学分析

he MAPK（mitogen-activated protein kinases）gene family cascade plays greatly important roles in signal transduction pathways, which is a important kind of kinase gene family in plant. In many physiological and biochemical processes, the plant MAPKs not only had influences on its resistance to environment, but also on its own growth and development, what's more, on cell death. At present, the research in MAPK gene family of cucumber is less. In this passage，we use Hidden Markov Model(HMM) technology of computational biology to establish the MAPK gene family search model, and then search the protein database of cucumber，13 MAPK genes were identified. Meanwhile, use these genes to establish the phylogenetic tree. Phylogenetic analysis divided the plant MAPK family members into four distinct groups (A-D), supported by highly significant bootstrap values. Evolution analysis showed that these MAPK genes were distributed in all the four groups, 7 out of the 13 CsMPKs belonged to group D. The first description of the whole MAPK members in cucumber would be the groundwork for the functional and mechanism investigation of MAPK gene family. Meanwhile, the phylogenetic tree would provide new strategies and methods for us in forcasting the functional of the genes as well as the evolution ways of the MAPK gene family.