一种基于烯烃氢碳化反应的拼接合成策略

Most of the molecules in the organism are structurally produced by paired splicing of simple molecules. The effect of this natural law on organic chemistry is that the use of simple blocks, based on the coupling reaction, can help developing effective strategies to solve complex molecular synthesis problems. In this paper, based on the hydrocarbonation of olefins, a class of splicing synthesis strategies using alkenyl alcohol-containing alkyl alcohol compounds as structural units was developed. The alkyl iodide and allyl alcohol were used as the model substrate in the reaction, and the rationality of the splicing strategy was verified. The product containing two allyl alcohol structural units was obtained efficiently by three - step reaction.