光遗传学系统数据库的构建及分析

Precise regulation of biological cell signals and molecular function is of vital importance in the field of precision medicine. The emergence of optogenetic makes it possible to accurately regulate cell signals and molecular functions in space and time. Optogenetics is the integration of Optics and Genetics, which enables light-sensitive protein to function as light responsible tools to regulate specific signaling pathways and molecular function by targeted expression of light-sensitive proteins at cellular level. After nearly 20 years\' development, a large number of optogenetic systems have been developed as research tools. In this paper, the key components of optogenetic systems and related information were collected through literature research and bioinformatic analysis, and OPSIMO, a database for regulating signaling pathways and molecular functions based on optogenetic systems was constructed. As the first open-access optogenetic system database, and the data provided by OPSIMO lays a solid foundation for the development of next generation optogenetic systems.