大黄酸及其衍生物生物活性进展
Progress in the biological activity of Rhein and its derivatives
大黄酸（rhein）又名1.8-二羟基-3-羧基蒽醌，来源于蓼科植物，是药用大黄，掌叶大黄，何首乌的根茎的主要成分，自从1844年，Schossberger等首次从大黄中提取纯化出大黄酸，大黄酸及其衍生物有在全合成、结构改造，生物活性方面的研究引起了人们广泛的关注，研究表明大黄酸及其衍生物显示了广泛的生物活性，有抗炎、抗肿瘤、抗菌、抗病毒、抗氧化、免疫抑制作用，利尿作用, 泻下作用，降糖调脂、保肝抗纤维化等多种药理活性，并且在治疗骨关节炎、糖尿病、肾病等疾病及协同抗肿瘤方面表现突出，甚至可以起到体内小分子调控的作用。本文综述了近几年大黄酸及其衍生物的生物活性。
Rhein，a main constituent of Rhubarb，is a well-characterized anti-inflammatory agent which has been used for treatment of inflammatory diseases such as ostarthritis，diabetic nephropathy etc．It also has certain synergic antitumor effect ． This paper reviews the recent studies on pharmacological actions ， including anti-inflammation，anti-tumor，anti-oxidation，weight loss and lipid lowering of rhein and its derivatives．The effects of rhein and its derivatives on digestive system，kidney，heart，blood vessels and bone are also reviewed．
王恒山、姚贵阳
医药卫生理论药学基础医学
药物化学，大黄酸，抗肿瘤，抗炎
Medicinal Chemistryrheinanti-inflammationantitumor
王恒山,姚贵阳.大黄酸及其衍生物生物活性进展[EB/OL].(2014-10-20)[2025-07-09].http://www.paper.edu.cn/releasepaper/content/201410-221.点此复制
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