电离辐射诱导肠道细胞部分电解质改变的研究

his article explores whether in vivo and in vitro, radiation can cause changes in electrolyte concentration in the intestinal cells, in order to find the cause of radiation-induced cell death in this direction.The mice abdomen were irradiated with X-ray for 15Gy, blood was collected at 15min, 30min, 1h, and 2h after irradiation. The concentration of K+, Cl-, etc. in the serum was measured with a biochemical analyzer. The HCT116 cells and sw480 cells were irradiated with 2Gy, and extracellular fluid and lysate were collected at 30min, 60min, 90min, 2h, 2.5h, and 3h after irradiation. The concentration of K+ and Cl- was measured by inductively coupled plasma spectroscopy, and the outflow ratio values were calculated. The results show that radiation can cause the outflow of intracellular K+, and it is speculated that the outflow of K+ may be the primary cause of radiation leading to late cell death.?????