Ethylene-triggered subcellular trafficking of CTR1 suppresses the response to ethylene gas
Ethylene-triggered subcellular trafficking of CTR1 suppresses the response to ethylene gas
Summary Ethylene gas controls plant growth and stress responses. Ethylene-exposed dark-grown seedlings exhibit a dramatic growth reduction, yet the seedlings rapidly return to the basal growth rate when ethylene gas is removed. However, the underlying mechanism governing this remarkable reversible acclimation of dark-grown seedlings to ethylene remains enigmatic. Here, we report that ethylene triggers the translocation of the Raf-like protein kinase CONSTITUTIVE TRIPLE RESPONSE1 (CTR1), a negative regulator of ethylene signaling, from the endoplasmic reticulum to the nucleus. Nuclear-localized CTR1 inhibits the ETHYLENE-INSENSITIVE3 (EIN3) transcription factor via the EIN3-BINDING F-box Proteins, resulting in rapid suppression of the ethylene response, thus promoting fast growth recovery. These findings uncover a mechanism of the ethylene signaling pathway that links the spatiotemporal dynamics of cellular signaling components to organismal responses.
Lee Han Yong、Seo Dong Hye、Park Chanung、Kieber Joseph J.、Park Hye Lin、Bakshi Arkadipta、Binder Brad M.、Yoon Gyeong Mee
Department of Botany and Plant Pathology, Purdue University||Center for Plant Biology, Purdue UniversityDepartment of Botany and Plant Pathology, Purdue University||Center for Plant Biology, Purdue UniversityDepartment of Botany and Plant Pathology, Purdue University||Center for Plant Biology, Purdue UniversityDepartment of Biology, University of North CarolinaDepartment of Botany and Plant Pathology, Purdue University||Center for Plant Biology, Purdue UniversityDepartment of Biochemistry & Cellular and Molecular Biology, University of TennesseeDepartment of Biochemistry & Cellular and Molecular Biology, University of TennesseeDepartment of Botany and Plant Pathology, Purdue University||Center for Plant Biology, Purdue University
植物学分子生物学细胞生物学
EthyleneCTR1Nuclear localizationSpatiotemporal regulationGrowth KineticsStress response
Lee Han Yong,Seo Dong Hye,Park Chanung,Kieber Joseph J.,Park Hye Lin,Bakshi Arkadipta,Binder Brad M.,Yoon Gyeong Mee.Ethylene-triggered subcellular trafficking of CTR1 suppresses the response to ethylene gas[EB/OL].(2025-03-28)[2025-04-27].https://www.biorxiv.org/content/10.1101/2020.06.12.148858.点此复制
评论