铜绿假单胞菌感染所致肺炎炎症"瀑布效应"的机制与中医药治疗

Pseudomonas aeruginosa is one of the most common resistant pathogen of nosocomial infection, with high detection rate, great resistance and high lethality, which make it become a thorny question to be solved. The core pathogenic mechanism of PA is that lipopolysaccharide activates TLR4 signal pathway and triggers inflammatory cascade reaction. Senile pneumonia is called wind warm and pulmonary heat disease in TCM. Deficiency of vital qi, toxicity-blood stasis syndrome is throughout this disease (senile pneumonia). The prescription of FuzhengJieduHuayu which came from a long period of clinical practice, is fit to the syndrome mentioned above and has significant effect in treating pneumonia caused by PA. The possible mechanismare the reversal of resistance, synergistic effect with antibiotics,suppression of inflammation and promotion of the rehabilitation.