基于角度离散化的基因调控网络定性分析

here is a hypothesis in the analysis of gene regulatory networks, if the time-series values of two genes change in a similar trend, the regulatory relationship may exists between these two genes. Therefore, the use of discretization of angle to deal with gene expression data will reflect the trend of change of gene expression values so as to make it possible to analyze the regulatory relation between genes qualitativly. At first, we drawed a line between the neighboring gene expression data. Thus an angle between the connected line and the horizontal line is formed..Secondly, we calculated those angles and applied them to replace the gene expression data. In the third step, we discretize the gene expression data into six states by comparing the neighboring angles according to the defined rule of angle discretization. The six ststes reflect not only the trend but also the change degree of gene expression values. In the end, the genes having regulatory relation will be identified through the substruction and the relative frequency methods.