恶性疟原虫对青蒿素类药物抗药性的最新研究进展
dvance in the research of resistance of Plasmodium falciparum to artemisinin and its derivatives.
恶性疟是一种致死性很高的全球性寄生虫病。由于长期抗疟药的使用，目前恶性疟原虫对氯喹等主要抗疟药物普遍产生抗药性，青蒿素类药物是在氯喹、奎宁抗药性产生后的主要替代治疗药，也是至今唯一没有出现普遍抗药性的抗疟药。但是，近年不少研究和临床观察发现青蒿素类药物的敏感性正逐渐下降，提示恶性疟原虫对青蒿素及其衍生物的抗药性正在形成。本文就近期青蒿素药抗药性的现状及其机制的研究进展情况进行了综述。
Plasmodium falciparem Malaria is one of the parasitic diseases of highest mortality. Up to the present，drugs like chloroquine have brought clearly drug resistance due to wildly used. Artemisinins are the only drugs without drug resistance and efficacious for the treatment of uncomplicated falciparum malaria.But recently many researches claim sensitivity of Plasmodium falciparum to artemisinin is falling .we are discussing the subject.
王颖娜、杨照青、张艳梅
医药卫生理论医学现状、医学发展基础医学
疟原虫青蒿素休眠现象抗药性现状
plasmodium falciparemartemisininsantimalarialdormant drug-resistant mechanism
王颖娜,杨照青,张艳梅.恶性疟原虫对青蒿素类药物抗药性的最新研究进展[EB/OL].(2013-07-05)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201307-98.点此复制
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