Characteristics and influence of type 2 diabetes in cirrhosis ascites with spontaneous bacterial peritonitis
Characteristics and influence of type 2 diabetes in cirrhosis ascites with spontaneous bacterial peritonitis
Abstract ObjectiveTo investigate the characteristics and influence of type 2 diabetes in hepatocirrhosis ascites complicated with spontaneous bacterial peritonitis(SBP) to support clinical management of this condition. MethodsA retrospective study was conducted to collect patients with hepatocirrhosis ascites with hospitalization from January 1, 2016 to June 30, 2019. The patients were classified according to whether they had type 2 diabetes and SBP. Univariate and multivariate binary logistic regression analysis were performed on the data of the two groups. ResultsA total of 214 patients were enrolled in the study, including 121 males and 93 females; 21 diabetics and 193 non diabetics; 119 SBP patients and 95 control subjects. There were 18 cases of SBP in hepatocirrhosis ascites complicated with diabetes, accounting for 85.7%, which was significantly higher than that in the non-diabetic group. The times of ascites, age and hospitalization days of cirrhotic ascites complicated with diabetes were 2 (1-3) times, 74 (60-76) years old and 25 (15-36) days, respectively, which were significantly higher than those in the non-diabetic group, P < 0.05. Multivariate analysis showed that diabetes, the times of hepatocirrhosis ascites, hospitalization days and total bilirubin (TBIL) increased the independent risk factors of SBP in hepatocirrhosis ascites, with OR values of 5.126 (1.358-19.345), 1.949 (1.428-2.660), 1.028 (1.010-1.047), 1.006 (1.001-1.010), respectively (P < 0.05). Conclusionthe patients with hepatocirrhosis ascites complicated with diabetes showed older age, longer hospitalization time, more SBP and more ascites; diabetes mellitus, times of ascites, hospitalization days and TBIL increased the risk of SBP in hepatocirrhosis ascites.
Zhang Lin、Li Xiaofei、Qi Ying、Zhang Xiaoyu、Qi Zhihong、Qin Xuzhen、Kong Xiangyi、Zhao Yang、Ma Hongyan、Wang Frank
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences||School of Population Medicine and Public Health, Chinese Academy of Medical Science & Peking Union Medical College||Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne||The University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer CentreThe Second Clinical College of Guangzhou University of Chinese MedicineSchool of Health Policy and Management, Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeThe Nossal Institute for Global Health, Melbourne School of Population and Global Health, The University of Melbourne||WHO Collaborating Centre on Implementation Research for Prevention & Control of NCDs, MelbourneDepartment of Geriatrics, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)Monash Medical Centre, Faculty of Medicine, Monash University
临床医学内科学
DiabetesSpontaneous bacillary peritonitisHepatocirrhosis ascites
Zhang Lin,Li Xiaofei,Qi Ying,Zhang Xiaoyu,Qi Zhihong,Qin Xuzhen,Kong Xiangyi,Zhao Yang,Ma Hongyan,Wang Frank.Characteristics and influence of type 2 diabetes in cirrhosis ascites with spontaneous bacterial peritonitis[EB/OL].(2025-03-28)[2025-05-01].https://www.medrxiv.org/content/10.1101/2020.09.25.20201798.点此复制
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