中国妇女上皮性卵巢癌中AIB1 CAG/CAA重复序列多态性的研究

o analysis the relationship between AIB1 CAG/CAA repeat polymorphism and epithelial ovarian cancer. 69 epithelial ovarian cancers, 19 borderline ovarian tumors, 25 benign ovarian tumors and 24 normal ovarian specimens were included in this study. PCR was used to examine AIB1 genetypes. Typical genotypes were selected and sequenced.1) The AIB1 CAG/CAA repeat length in Chinese women ranged from 26 to 29, with the most common repeat length being 29. Homozygous 29/29 and heterozygous 28/29 were the most common genotypes, with 35.77% (49/137) and 49.64% (68/137) harboring these genotypes, respectively.2) The frequency of a short AIB1 genotype (with ≤28 CAG/CAA repeats ) in epithelial ovarian cancers、borderline ovarian tumors、benign ovarian tumors and normal ovarian specimens was 14.49%（10/69）、10.53%（2/19）、4.0%（1/25）、0, respectively. There is no statistic difference in those samples（P＞0.05）.3) No difference of AIB1 CAG/CAA repeat polymorphism was found according to the histological differentiation, FIGO stagings, grades and lymph node involvement（P＞0.05）.Based on the findings in this study, it is suggested that short AIB1 genotypes (with ≤28 CAG/CAA repeats) are not a strong predictor of risk factors of epithelial ovarian cancer in Chinese women. There is no evidence that AIB1 CAG/CAA repeat polymorphism is related to the histological differentiation, clinical staging, grades and lymph node involvement. Considering our study is small, the results need to be convinced by studies in more samples.