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首页|Distinct kinetics in antibody responses to 111 Plasmodium falciparum antigens identifies novel serological markers of recent malaria exposure

Distinct kinetics in antibody responses to 111 Plasmodium falciparum antigens identifies novel serological markers of recent malaria exposure

Distinct kinetics in antibody responses to 111 Plasmodium falciparum antigens identifies novel serological markers of recent malaria exposure

来源:medRxiv_logomedRxiv
英文摘要

Abstract Strengthening malaria surveillance is a key intervention needed to reduce the global disease burden. Reliable serological markers of recent malaria exposure could dramatically improve current surveillance methods by allowing for accurate estimates of infection incidence from limited data. We studied the IgG antibody response to 111 Plasmodium falciparum proteins in travellers followed longitudinally after a natural malaria infection in complete absence of re-exposure. We identified a novel combination of five serological markers (GAMA, MSP1, MSPDBL1 C- and N-terminal, and PfSEA1) that detect exposure within the previous 3-months with >80% sensitivity and specificity. Using mathematical modelling, we examined the antibody kinetics and determined that responses informative of recent exposure display several distinct characteristics: rapid initial boosting and decay, less inter-individual variation in response kinetics, and minimal persistence over time. These serological exposure markers can be incorporated into routine malaria surveillance to guide efforts for malaria control and elimination.

Mwai K、White M T、Kibinge N、Sond¨|n K、Murungi L、Chege T、Yman V、Kamuyu G、Tuju J、Sundling C、Asghar M、Osier F H A、Nyamako L、Kiboi D、F?rnert A、Kimathi R、Kiyuka P、Chepsat E

Kenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-Coast||Epidemiology and Biostatistics Division, School of Public Health, University of the WitwatersrandDepartment of Parasites and Insect Vectors, Institut PasteurKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-CoastDivision of Infectious Diseases, Department of Medicine Solna and Center for Molecular Medicine||Department of Infectious Diseases, Karolinska, University HospitalKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-CoastKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-CoastDivision of Infectious Diseases, Department of Medicine Solna and Center for Molecular Medicine||Department of Infectious Diseases, S?dersjukhusetKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-CoastKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-CoastDivision of Infectious Diseases, Department of Medicine Solna and Center for Molecular MedicineDivision of Infectious Diseases, Department of Medicine Solna and Center for Molecular MedicineKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-Coast||Centre for Infectious Diseases, Parasitology, Heidelberg University HospitalKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-CoastKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-CoastDivision of Infectious Diseases, Department of Medicine Solna and Center for Molecular Medicine||Department of Infectious Diseases, Karolinska, University HospitalKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-CoastKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-CoastKenya Medical Research Institute - Wellcome Trust Research Program, Centre for Geographical Medicine Research-Coast

10.1101/2020.12.14.20242768

医药卫生理论医学研究方法预防医学

Antibodyserological signaturestravellerlongitudinalmalariaPlasmodium falciparumserologyIgGexposure

Mwai K,White M T,Kibinge N,Sond¨|n K,Murungi L,Chege T,Yman V,Kamuyu G,Tuju J,Sundling C,Asghar M,Osier F H A,Nyamako L,Kiboi D,F?rnert A,Kimathi R,Kiyuka P,Chepsat E.Distinct kinetics in antibody responses to 111 Plasmodium falciparum antigens identifies novel serological markers of recent malaria exposure[EB/OL].(2025-03-28)[2025-05-17].https://www.medrxiv.org/content/10.1101/2020.12.14.20242768.点此复制

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