自体免疫细胞治疗临床研究进展

In passed few years immunotherapy has played a critical role in treating most types of cancer. Adoptive immnue cell therapy is one of the hotest cancer immunotherapy, including therapies of Cytokine-induced Killer Cells (CIKs), Autologous activated lymphocyte(AAL), Cytotoxic T Lympercytes (CTLs), Dentritic Cells(DCs) and Chimeric Antigen Receptor T-cell (CAR-T). Through transfused cytokines stimulation or gene modification of in-vitro cultured autologous immune cells,the activated immnue cells kill tumour cell to eradicate tumor in patients. A large number of clinical data already proved the potent efficiency of this kind of treatment in various cancer patients. In this review, we focus on the adoptive immune cell preparation and the main cancer cell killing mechanism. Here we refer an important referential value for futher studying on adoptive immunotherapy in clinic, especially cooperating with radiotherapy and chemotherapy. Thus, it has important values on science and clinical application.