短期空气质量变化对人体免疫功能的影响

Objective: Observing the impact of short-term changes of ambient air pollution on healthy young people in immune function. Method: In the period time of 2008 Olympic games in Beijing, detecting changes of API and main pollutant of air pollution in the center area of Beijing, Selecting 128 healthy young people, detecting different kind of biological parameters , including changes of lymphocytes' immunophenotype by flow cytometry, and T cell receptor rearrangement excision circles (TRECs) by real-time in June 2008 to October 2008. Using the ANOVA of statistical software package of SPSS 12.0 to analysis the correlation of changes between air quality and biological parameters; analysis the relationship between the changes of air pollutants and biological parameters by the model of two level random intercept of statistical software of STATA9.0. Results: 1. The air quality was obviously improved during the games. 2. The immunology parameters had changed obviously during the games as the changes of the air pollution: As the quality of ambient air turned better, TH, TH/TS, Tregs had increased, while TS , TRECs, NK cells had decreased obviously. 3. The changes of the concentration of PM2.5 was proved to have statistical significance with the changes of TH, TH/TS, Tregs and TRECs. Conclusion: Short-term changes of air pollutants have obviously impact on healthy people's immunology parameters. Along with the improvement of the air quality, immunology parameters representing the function of immune monitoring increased.