海带多糖干预动脉粥样硬化发生的炎性调控机制

Laminaria japonica is an important marine vegetable with great health-benefits for preventing cardiovascular disease. The aim of the present work was to study the anti-atherosclerosis activity of L. japonica polysaccharide using the LDLr-/- mouse model of atherosclerosis induced by high fat diet. The obtained results showed that L. japonica polysaccharide can not only attenuate the formation of atherosclerotic plaques, but also significantly inhibit the vascular inflammation in mice, indicating that the inhibition of inflammation could be one of the underlying mechanism for L. japonica polysaccharide to resist atherosclerosis.