β-地中海贫血表型的修饰因子――胎儿血红蛋白表达水平的分子调控
he molecular factors affecting the expression level of fetal hemoglobin
胎儿血红蛋白（HbF）是在胎儿期间大量存在的血红蛋白，成年人体内含量极少，低于1%。但是不少成年人的HbF表达水平较高。HbF表达水平的高低，是β-地中海贫血表型的修饰因素。根据一系列的研究表明，HbF表达水平增高的分子机制主要是β珠蛋白基因簇自身变异和其他基因的影响。了解这些分子因素，可为阐明HbF的内在调控机制提供新的线索，并有助于开发新的β-地中海贫血治疗方法。
Fetal hemoglobin (HbF), which expresses mainly in fetal period, expresses rarely in adults, and it's about less than 1%. But many adults have high level of expression of HbF. A lot of research has showed that the molecular mechanism of high levels of HbF in adults is related to the mutation in β-globin gene cluster and other genes., It is useful in elucidating the internal mechanism of expression of HbF, and providing new clues to develop new treatments to thalassemia patients.
商璇、黄才博
基础医学分子生物学
医学遗传学胎儿血红蛋白基因突变
Medical GeneticsFetal hemoglobinGene mutations
商璇,黄才博.β-地中海贫血表型的修饰因子――胎儿血红蛋白表达水平的分子调控[EB/OL].(2011-11-10)[2025-07-22].http://www.paper.edu.cn/releasepaper/content/201111-164.点此复制
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