童年逆境对应激反应的影响及其神经生理机制

Childhood adversity can significantly increase the risk of depression, anxiety and other psychological disorders. An abnormal stress response is one of the important factors causing these psychological disorders.Childhood adversity may affect the activation of the HPA axis and enhance or decrease the sensitivity of stress response. Severe childhood adversity may increase the sensitivity of individual stress response, but mild and moderate childhood adversity may also produce protective "stress inoculation" effect.This paper expounds the influence mechanism of childhood adversity on stress response from three aspects: brain function, immune system and epigenetics.Future research should pay attention to controlling irrelevant variables and further explore the influence of different childhood adversities on stress response."