厚朴酚抗金黄色葡萄球菌生物膜活性研究

It has been shown that magnolol, an active component isolated from the traditional medicinal plant Certex Magnoliae Officinalis in China , has antimicrobial activity against a variety of bacteria and fungi. In this study, we demonstrate that magnolol shows antimicrobial effects against S.aureus grown in planktonic and biofilm cultures.Coverslides was used to grow S.aureus biofilms in 6-well plates and magnolol at different concentrations was edded to the plates to observe the morphology of biofilms after the drug interaction.The rusults show that the MIC and MBC of magnolol for S.aureus in suspension and bio?lm are 4 and 16μg/mL respectively, while the MIC and MBC of magnolol for S.aureus inbiofilms are 64 and >512μg/mL respectively. It is obvious that magnolol has antimicrobial effects against S. aureus grown in planktonic and bio?lm cultures. Even better,it can destroy the established biofilms produced by S. aureus. These results indicate that magnolol may serve as a promising lead compound for future antimicrobial drug development.