脑桥自发性活动的降低可能是青少年冲动行为的生物标记：静息态磁共振成像研究
ecreased spontaneous brain activity in the pons is associated with neural mechanisms of impulsivity in adolescents: resting-state fMRI study
目的 探索单胺氧化酶A基因多态性对健康男性青少年静息状态下脑基础活动的影响。方法 对31例MAOA 低活性的健康男性青少年及25例MAOA 高活性的健康男性青少年进行静息态磁共振成像扫描，采用低频振幅(ALFF)的方法, 比较两组被试全脑各区域ALFF值的大小差异。然后将有显著性差异的脑区作为ROI，提取ROI中的ALFF值，并对个体的ROI ALFF值与Barratt's 冲动量表分数做相关。结果 与MAOA 高活性的健康男性青少年相比，MAOA 低活性的被试在脑桥区域ALFF值显著降低。此外，在MAOA 低活性的群体中，个体脑桥的ALFF值与BIS值呈显著正相关。结论 MAOA基因多态性与脑桥的自发神经活动存在一定关联性，MAOA 低活性的健康男性青少年所存在的脑桥部位自发性脑部活动的降低可能是冲动及攻击的一个重要危险因素。
Objective：To examine the effects of a functional polymorphism of the monoamine oxidase A (MAOA) gene on spontaneous brain activity in healthy male adolescents. Methods: Resting-state fMRI was performed on 31 healthy male adolescents with the low-activity MAOA genotype (MAOA-L) and 25 healthy male adolescents with the high-activity MAOA genotype (MAOA-H). The amplitude of low-frequency fluctuation (ALFF) of the blood oxygen level-dependent (BOLD) signal was calculated using REST software, and was compared between genotype groups. The regions showed significant difference were defined as ROIs. The ALFF data in ROIs were related to BIS scores. Results: Compared with the MAOA-H group, the MAOA-L group showed significantly decreased ALFF in the pons. In addition, the BIS scores were positively correlated with ALFF in pons in the MAOA-L group, but not in the MAOA-H group. Conclusions: Decreased spontaneous brain activity in the pons of the MAOA-L male adolescents may provide a neural mechanisms by which boys with the MAOA-L genotype confers risk for impulsivity and aggression.
姚树桥、朱熊兆、雷辉、张小崔
基础医学神经病学、精神病学生物科学研究方法、生物科学研究技术
单胺氧化酶A基因可变数目重复序列多态性低频振幅功能磁共振成像
monoamine oxidase A genevariable number tandem repeatamplitude of low-frequency fluctuationfunctional Magnetic Resonance Imaging
姚树桥,朱熊兆,雷辉,张小崔.脑桥自发性活动的降低可能是青少年冲动行为的生物标记：静息态磁共振成像研究[EB/OL].(2014-08-18)[2025-08-18].http://www.paper.edu.cn/releasepaper/content/201408-162.点此复制
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