“Monozygotic twins discordant for severe clinical recurrence of COVID-19 show drastically distinct T cell responses to SARS-Cov-2”
“Monozygotic twins discordant for severe clinical recurrence of COVID-19 show drastically distinct T cell responses to SARS-Cov-2”
ABSTRACT BackgroundClinical recurrence of COVID-19 in convalescent patients has been reported, which immune mechanisms have not been thoroughly investigated. Presence of neutralizing antibodies suggests other types of immune response are involved. MethodsWe assessed the innate type I/III IFN response, T cell responses to SARS-CoV-2 with IFNγ ELISPOT, binding and neutralizing antibody assays, in two monozygotic twin pairs with one COVID-19 recurrence case. ResultsIn pair 1, four months after a first mild episode of infection for both siblings, one displayed severe clinical recurrence of COVID-19. Twin pair 2 of siblings underwent non-recurring asymptomatic infection. All fours individuals presented similar overall responses, except for remarkably difference found in specific cellular responses. Recurring sibling presented a reduced number of recognized T cell epitopes as compared to the other three including her non-recurring sibling. ConclusionsOur results suggest that an effective SARS-CoV-2-specific T cell immune response is key for complete viral control and avoidance of clinical recurrence of COVID-19. Besides, adaptive immunity can be distinct in MZ twins. Given the rising concern about SARS-CoV-2 variants that evade neutralizing antibodies elicited by vaccination or infection, our study stresses the importance of T cell responses in protection against recurrence/reinfection. Key pointsImmune parameters leading to COVID-19 recurrence/reinfection are incompletely understood. A COVID-19 recurrence case in a monozygotic twin pair is described with an intact antibody and innate type I/III Interferon response and drastically reduced number of recognized SARS-CoV-2 T cell epitopes.
Boscardin Silvia B.、Jacintho Lucas C.、Kuramoto Andreia、Maciel Rui M. B.、Naslavsky Michel S.、Cunha-Neto Edecio、Bruno Fernanda R.、Apostolico Juliana S.、Bruni Miriam、Yamamoto Marcio M.、Kalil Jorge、Levin Gabriel、Scliar Marilia O.、Nunes Kelly、Neto Miguel Mitne、Wang Jaqueline Y. T.、Zatz Mayana、Magawa Jhosiene Y.、Santos Keity S.、Lima Ariane C.、Fernandes Edgar R.、Coria Vivian R.、Coelho Veronica P.、Almeida Rafael R.、Silva Monize V. R.、Rosa Daniela S.、Castelli Erick C.、Matos Larissa R. B.、Passos-Bueno Maria Rita、S. Nunes Jo?o Paulo、Castro Mateus V. de
Laboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Division of Clinical Immunology and Allergy, Department of Medicine, Faculdade de Medicina da Universidade de S?o Paulo (FMUSP)||Department of Parasitology, Biosciences Institute, Universidade de S?o Paulo, S?o PauloLaboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o Paulo||Division of Clinical Immunology and Allergy, Department of Medicine, Faculdade de Medicina da Universidade de S?o Paulo (FMUSP)Laboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o Paulo||Division of Clinical Immunology and Allergy, Department of Medicine, Faculdade de Medicina da Universidade de S?o Paulo (FMUSP)Fleury Laboratory, S?o PauloHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o PauloLaboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o PauloLaboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o Paulo||Division of Clinical Immunology and Allergy, Department of Medicine, Faculdade de Medicina da Universidade de S?o Paulo (FMUSP)Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o Paulo||Department of Microbiology, Immunology and Parasitology, Universidade Federal de S?o Paulo (UNIFESP/EPM), S?o PauloDepartment of Parasitology, Biosciences Institute, Universidade de S?o Paulo, S?o PauloDepartment of Parasitology, Biosciences Institute, Universidade de S?o Paulo, S?o PauloHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o Paulo||Laboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o PauloLaboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o PauloHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o PauloHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o PauloFleury Laboratory, S?o PauloHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o PauloHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o PauloLaboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o Paulo||Division of Clinical Immunology and Allergy, Department of Medicine, Faculdade de Medicina da Universidade de S?o Paulo (FMUSP)Laboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o Paulo||Division of Clinical Immunology and Allergy, Department of Medicine, Faculdade de Medicina da Universidade de S?o Paulo (FMUSP)Laboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o Paulo||Division of Clinical Immunology and Allergy, Department of Medicine, Faculdade de Medicina da Universidade de S?o Paulo (FMUSP)Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o Paulo||Department of Microbiology, Immunology and Parasitology, Universidade Federal de S?o Paulo (UNIFESP/EPM), S?o PauloHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o PauloLaboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o Paulo||Division of Clinical Immunology and Allergy, Department of Medicine, Faculdade de Medicina da Universidade de S?o Paulo (FMUSP)Laboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o PauloHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o PauloLaboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Department of Microbiology, Immunology and Parasitology, Universidade Federal de S?o Paulo (UNIFESP/EPM), S?o PauloSchool of Medicine, Universidade Estadual Paulista (UNESP)Human Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o PauloHuman Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o PauloLaboratory of Immunology, Heart Institute (InCor), Hospital das Cl¨anicas da Faculdade de Medicina da Universidade de S?o Paulo, (HCFMUSP), S?o Paulo||Institute for investigation in Immunology ¨C Instituto Nacional de Ci¨oncia e Tecnologia ¨C iii-INCT, S?o Paulo||Division of Clinical Immunology and Allergy, Department of Medicine, Faculdade de Medicina da Universidade de S?o Paulo (FMUSP)Human Genome and Stem Cell Research Center (HUG-CELL), Biosciences Institute, Universidade de S?o Paulo
医学研究方法基础医学
COVID-19 recurrenceSARS-CoV-2 reinfectionhealth care workerImmune responseMonozygotic Twins
Boscardin Silvia B.,Jacintho Lucas C.,Kuramoto Andreia,Maciel Rui M. B.,Naslavsky Michel S.,Cunha-Neto Edecio,Bruno Fernanda R.,Apostolico Juliana S.,Bruni Miriam,Yamamoto Marcio M.,Kalil Jorge,Levin Gabriel,Scliar Marilia O.,Nunes Kelly,Neto Miguel Mitne,Wang Jaqueline Y. T.,Zatz Mayana,Magawa Jhosiene Y.,Santos Keity S.,Lima Ariane C.,Fernandes Edgar R.,Coria Vivian R.,Coelho Veronica P.,Almeida Rafael R.,Silva Monize V. R.,Rosa Daniela S.,Castelli Erick C.,Matos Larissa R. B.,Passos-Bueno Maria Rita,S. Nunes Jo?o Paulo,Castro Mateus V. de.“Monozygotic twins discordant for severe clinical recurrence of COVID-19 show drastically distinct T cell responses to SARS-Cov-2”[EB/OL].(2025-03-28)[2025-04-28].https://www.medrxiv.org/content/10.1101/2021.03.26.21253645.点此复制
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