催化不对称Pictet-Spengler反应研究进展
Recent development on catalytic asymmetric Pictet-Spengler reaction
具有光学活性的四氢异喹啉和四氢-β-咔啉是两种十分重要的环状骨架，其衍生物表现出许多生物、生理活性。催化不对称Pictet-Spengler反应是合成这类化合物最经济有效的途径之一，受到了化学工作者的极大关注。本文综述了近年来催化色胺与醛、酮的不对称Pictet-Spengler反应的研究进展，并对今后的发展方向作了展望。
Optically active tetrahydroisoquinoline and tetrahydro-β-carboline are core structural elements possessing a wide range of important biological and pharmaceutical properties. The Pictet-Spengler reaction is one of the most direct, efficient and prevailing method to construct these ring systems. In this paper, the recent progress on the catalytic asymmetric Pictet-Spengler reaction between tryptamine and aldehyde or ketone has been briefly described.?????
刘小华、赵剑楠、林丽丽、冯小明
化学
有机化学四氢-β-咔啉不对称催化Pictet-Spengler反应
Organic chemistrytetrahydro-β-carbolineasymmetric catalysisPictet-Spengler reaction
刘小华,赵剑楠,林丽丽,冯小明.催化不对称Pictet-Spengler反应研究进展[EB/OL].(2010-10-20)[2025-08-18].http://www.paper.edu.cn/releasepaper/content/201010-363.点此复制
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