大鼠实验性流产模型的建立及黄芪多糖对其的影响
Establishment of LPS-induced Abortion in Rats and the Effect of Astragalus Polyaccharin
本实验采用怀孕7天SD大鼠尾静脉注射细菌脂多糖，建立大鼠流产模型，随机分为正常对照组、流产模型组、黄芪多糖组，对照组与模型组分别于4~9天口服生理盐水2ml/日，黄芪多糖组于怀孕4～9天口服黄芪多糖2ml/日，实验第10天麻醉处死各组大鼠，计数妊娠成功率和流产率，以研究黄芪多糖对实验性流产大鼠保胎的作用。结果表明：LPS诱导大鼠流产模型流产率高达72.73%，而对照组和黄芪多糖组流产率分别为8.33%和16.67%，与模型组比较差异极显著（P<0.01）。LPS可以诱导建立大鼠流产模型，中药成分黄芪多糖对实验性大鼠流产具有一定的保护作用。
Spragye Dawley SD rats injected with Lipopolysaccharides LPS 1冚g in tail vein on Day 7 of pregnancy were used as aborting model. The rats were randomly divided into 3 groups: the control group, the abortion model group and the group treated with the Astragalus Polyaccharin. The control group and the abortion model group were given normal saline 2ml from Day 4 to Day 9 of pregnancy via gastrogavage, the treated group were given Astragalus Polyacchari 2ml during the same period. All the rats were killed on Day 10 of pregnancy, abortion ratios were assessed. A high miscarriage rate up to 72.73% was observed in the LPS induced abortion group in contrast to the control group, which was only 8.33%. Abortion rate induced by LPS was decreased after treatment with Astragalus Polyaccharin.
赵兴绪、魏彦明
基础医学妇产科学中医学
大鼠实验性流产模型黄芪多糖
ratsexperiment abortion modelstragalus Polyacchari
赵兴绪,魏彦明 .大鼠实验性流产模型的建立及黄芪多糖对其的影响[EB/OL].(2009-09-17)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/200909-478.点此复制
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