降糖孜亚比提片对血糖和血脂作用的实验研究

im To study the effects of Hypoglycemic Ziyabiti Tablet (HZT) extracts on blood glucose 、blood lipid and metabolism in type 2 diabetic rats. Methods After Wistar rats were administrated with high fat emulsion for 10 days, we assessed the insulin resistance by using blood capillary method. They were injected alloxan (ALX) to abdominal cavity in continuous two days , and then type 2 diabetic rat model was established . The rats were divided into normal control group，model group，HZT treated group(440、220 mg•kg-1•d-1) and positive control Xiaoke Wan (XKW) treated group（420 mg•kg-1•d-1）. Results The KITT (exponent of insulin sensitivity) of Wistar rats was 5.8±0.5 in normal control group and 2.8±0.9 in model group (P﹤0.01). Compared with model group, the FBG and TC level in the high-dose and low-dose HZT treated group were decreased and the HDL-C level was increased (P﹤0.05); the FINS level in the high-dose HZT treated group was increased (P﹤0.05) ; the number of IS in the high-dose and low-dose HZT were enlarged (P﹤0.05) . Conclusion HZT could decrease the T2DM rats’FBG and TC level , which hinted the hypoglycemic mechanism was possibly to promote insulin secretion and increase the utilization of glucose .