NA甲基转移酶抑制剂在急性髓系白血病中的应用与进展

cute myeloid leukemia(AML) is a malignant blood diseases and it has great harm to human health. DNA methylation mainly refers to the abnormal genomic CpG island methylation, which occurs abnormal gene expression. DNA methyl transferase is a key enzyme, which plays an important role in epigenetic regulation of gene expression and inhibition. Through the possible relationship between DNA methylation molecular abnormalities and AML, it occurrs analysis describes the possible pathogenesis of AML. In recent years, the studys found that some tumor suppressor genes and tumor-related gene hypermethylation are closely related to development of AML. For example RIL, ID4, SFRP family and so on. The mechanism using 5-azactidine and Decitabine treatment of AML is unknown and the use-method is different. Further investigation will afford theoretical principle for individualized treatment. AML is a disease caused by various factors, whose direction of the molecular target is hoping for further treatment breakthrough , and may be considered in combination use of medicine.