凝溶胶蛋白与阿尔茨海默症

he presence of amyloid plaques is one of the neuropathological features of Alzheimer's disease (AD). Amyloid plaques consist mainly of beta-amyloid peptide (Aβ). Accumulating experimental evidence shows that, targeted at Aβ, clearance of amyloid plaque is helpful for improving recognation ability, and will be an important strategy for the treatmet of AD. Gelsolin is an important actin-binding protein. Results from several research groups show that gelsolin inhibits the aggregation of Aβ into fibrils, and also disaggregates the preformed Aβ fibrils. More importantly, gelsolin reduces amyloid plaques and decreases the level of Aβ in transgenic mouse models of AD. In the future gelsolin will be possiblely used in the prevention and treatment of AD.