肾素前体与原发性高血压患者左室重构无关

Purpose Left ventricular remodeling (LVR) is a manifestation of the target organ damage caused by hypertension. Although some studies using animal models have attempted to address the link between elevated prorenin and tissue remodeling in patients with both hypertension and diabetes mellitus, the results have been contradictory. This research aims to find out whether prorenin is correlated to left ventricular remodeling. Methods There are 94 cases with essential hypertension (EH) were enrolled in the study. Prorenin was detected by ELISA, meanwhile left ventricular mass index (LVMI) and relative wall thickness (RWT) were applied to evaluate left ventricular structure by Two-dimensional echocardiography. Subjects were divided into two groups according to whether they have LVR or not, as well as diabetes mellitus. SPSS 19 statistical software was applied to analyse the data. T test was used to compare the differences between two groups. Simple linear correlation was used to analyse the correlation of prorenin and each factor. Results 1. Comparison between group of normal left ventricular geometric shape and group of left ventricular remodeling , prorenin have no difference between the two groups (P > 0. 05); Differences of diastolic blood pressure are significant between groups (P < 0. 05); Difference of systolic blood pressure is significant (P < 0. 01). 2. In all subjects, prorenin is not correlate with age, FPG, systolic blood pressure, diastolic blood pressure, pulse pressure, LVMI or RWT (P > 0.05). Conclusions 1. Prorenin level is not significantly increased in hypertensive patients with left ventricular remodeling compared to hypertensive patients with normal left ventricular geometric shape. Prorenin is not correlate with LVMI or RWT. 2. Prorenin is not correlate with age, FPG, systolic blood pressure, diastolic blood pressure or pulse pressure. ?????