应用Ullmann型交叉偶联反应合成2-芳基-3-氧代丁酸酯的研究
Studies on the Synthesis of 2-aryl-3-oxobutanoate via Ullmann type Cross-coupling Reaction
本文对应用Ullmann交叉偶联反应合成重要药物合成中间体2-（2-氟-3甲氧基）-苯基-3-氧代丁酸酯的合成方法进行了较系统的研究，发现了溶剂效应对偶联反应的重要影响，对于改进目标药物合成方法有重要意义。
In this paper, a systematic study was carried out on a novel pharmaceutical synthesis intermediate 2-(2-fluoro-3-methoxyl)phenyl-3-oxobutyrate which was synthesized by Ullmann coupling reaction. The experimental results imply an important solvent effect on the cross-coupling reaction, which was of great significance for improving the synthesis method of target drug.
秦楠、邓军、何玲、李卫东
制药化学工业
合成化学 2-芳基-3-氧代丁酸酯 Ullmann型交叉偶联反应 溶剂效应
synthetic chemistry 2-aryl-3-oxobutyrate UIImann type cross-coupling reaction solvent effect
秦楠,邓军,何玲,李卫东.应用Ullmann型交叉偶联反应合成2-芳基-3-氧代丁酸酯的研究[EB/OL].(2019-04-30)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201904-371.点此复制
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