左金丸有效部位PH-敏感凝胶剂成型工艺研究

im: making effective parts of the effective parts of ZuoJin prescription into PH-sensitive gel, in order to study the method of new preparation that can administration by PH-sensitive and self-regulation.Method: The study selected biodegradable biopolysaccharides chitosan as monomer, polyvinylpyrrolidone (PVPK30) as framework material, and Formaldehyde Solution as the initiator to prepare gel carrying agent to determined the best gel synthesis technology.And make pH-sensitive gel of effective parts of ZuoJin prescription and the influence of the gel modeling technique the feeding sequence in the target of the rate of carrying medicine.Results: It can make identification of the gel synthesis technique under the condition of PH=1 having a best sensitive swelling. When putting xerogel into the solution of effective parts of ZuoJin prescription (PH=1), after full of swelling, the rate of carrying medicine of 11.26%.Conclusions: This study got result of best rate about concentration of chitosan, polyvinylpyrrolidone(PVP) and the quantity of formaldehyde, and took the preliminary research about modeling technique, but the molding results of the study indicated that the current gel containing small amount of drugs, and needed a further study.