银催化苯并噻唑的Csp2-H的酰基及芳基化反应研究

silver-catalyzed acylation of benzothiazole have been reported in aqueous media. A variety of aroyl substituted benzothiazoles were obtained from readily available alpha-ketone acids and benzothiazole. The reaction displays good functional group tolerance, mild conditions and high chemoselectivity, thus providing facile and environmentally friendly approach to valuable benzothiazole in moderate to good yields. This method is based on a decarboxylative radical acylation of heterocycles. Furthermore, the direct arylation of benzothiazole using boronic acids as aryl sources has aslo described in this paper.