一种基于基因芯片的癌症分类方法
Cancer Recognition Method Based on DNA Microarray
准确的癌症分类对于癌症研究和临床诊断都具有十分重要的意义。近年来,人们提出了多种基于基因芯片的癌症分类方法,但对于小样本集的多分类问题,一直没有很好的解决办法。我们提出了一种利用仿生模式识别理论对多类癌症样本进行计算机自动分类的方法。应用该方法,我们对癌症数据集GCM中的14类癌症样本和1类正常组织样本进行了实验。实验结果表明,仿生模式识别的平均正确识别率为80%,正确拒识率为81%。
he accurate cancer classification is of great importance in clinical treatment. Recently, the DNA microarray technology provides a promising approach to the diagnosis and prognosis of cancer types. However, it has no perfect method for the multiclass classification problem. The difficulty lies in the fact that the data are of high dimensionality with small sample size. This paper proposed an automatic classification method of multiclass cancers based on biomimetic pattern recognition (BPR). To the public GCM data set, the average correct classification rate reaches 80% under the condition that the correct rejection rate is 81%.
翟亚锋、王库、安冬、苏谦、王守觉
生物科学研究方法、生物科学研究技术肿瘤学
癌症分类仿生模式识别
ancerClassificationBiomimetic pattern recognition
翟亚锋,王库,安冬,苏谦,王守觉.一种基于基因芯片的癌症分类方法[EB/OL].(2009-02-26)[2025-08-23].http://www.paper.edu.cn/releasepaper/content/200902-1366.点此复制
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