碱性氨基酸调节PLGA体外降解特性的研究
Effect of basic amino acid upon the degradation property of PLGA in vitro
目的：在体外下考察碱性氨基酸对聚乳酸-聚羟基乙醇酸共聚物降解后集酸程度的缓解能力。材料方法：将赖氨酸、组氨酸、精氨酸分别各按5%和10%的比例与PLGA制成复合物，于体外在37℃下在三蒸水中进行降解2个月；通过总体观察、降解液PH的变化、复合物的失重率等指标来考察碱性氨基酸对PLGA体外降解特性的调节作用，同时将碱性氨基酸的调节效果与海藻酸钠、壳聚糖、碳酸氢钠的进行对比。结果：各种碱性添加剂都有一定的缓解酸度的能力， NaHCO3的缓解能力最强，海藻酸钠和壳聚糖的缓解能力较低，而碱性氨基酸的缓解能力适中；赖氨酸为5%时的添加量时能够得到较佳的综合调节缓解效果。结论：碱性氨基酸能有效地缓解PLGA降解后的集酸程度。
Purpose: To in vitro investigate the effect of basic amino acid upon relieving the level of acid collection in the course of PLGA degradation. Materials and methods: The composite was respectively prepared by blending Lysine, Histidine, Arginine with PLGA, while the composite respectively prepared by blending Algin, chitosan, NaHCO3 with PLGA as the comparison and the pure PLGA as the control. All composites were degradated in tri-distilled-water at 37℃ for 7 weeks. The degradation property of PLGA with the addition of basic additives was investigated by using gross observation, the pH change of degradation solution and the mass loss ration of the composite. Result: All the basic additives investigated in the experiment showed good potential to relieve the level of acid collection in the course of PLGA degradation. Among those, the relieving ability of NaHCO3 was in the top, basic amino acid in the moderate, while Algin and chitosan ranked lower. 5% addition of Lysine produced a best outcome. Conclusion: Basic amino acid can efficiently relieve the level of acid collection in the course of PLGA degradation
杨力、徐志玲、王为、刘彬、李校坤 、蔡绍皙、李明晖、麻开旺、宋保罗
生物化学高分子化合物工业药学
PLGA降解碱性氨基酸酸度调节
PLGA degradation basic amino acid PH regulation
杨力,徐志玲,王为,刘彬,李校坤 ,蔡绍皙,李明晖,麻开旺,宋保罗.碱性氨基酸调节PLGA体外降解特性的研究[EB/OL].(2006-11-07)[2025-05-22].http://www.paper.edu.cn/releasepaper/content/200611-138.点此复制
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