辛伐他汀干预实验性动脉粥样硬化兔模型

Objective To investigate whether simvastatin on atherosclerosis (AS) rabbit model of nuclear factor-KB (NF-KB) expression and inhibit the related impact on inflammatory cytokines TNF-α, IL-1 and MCP-1. Methods 40 male Japanese rabbits were randomly divided into blank control group, model group, simvastatin group, with the exception of the control group, the other in each group to establish aortic atherosclerosis model, from the beginning of the experiment day 1 early intervention to simvastatin, 10 were killed over the weekend after the anesthesia line access aortic NF-KB immunohistochemical staining, and the experimental dynamic 0,3,6,10 weeks in serum TNF-α, IL-1 and MCP-1 content. The results of the model group in plaque foam cells the expression of NF-κBp65 subunit rich group of symplectic cutting subunit NF-κBp65 positive cells than the expression of model group decreased plaque area of NF-κB p65 subunit expression significantly inhibited . Model group at different time points in serum TNF-α, IL-1 and MCP-1 concentration was significantly higher (P <0.01), Simvastatin cutting treatment group at each time point in varying degrees to reduce IL-1, TNF-α and MCP-1 level of the role of (P <0.05 or P <0.01). Conclusions Simvastatin reduces NF-κBp65 plaque areas subunit expression, at different time points on the release of inflammatory cytokines inhibit.