牵牛子肾毒性部位研究

Morning glory seed was a widely used traditional Chinese medicine for clearing damp and promoting diuresis. Recent years, the adverse reaction reports about the nephrotoxity of this herb has drawn much attention from medical circles. This research was designed to investigate the nephrotoxity of n-butanol, acetoacetate and petroleum benzine layer from the ethanol extract of morning glory seed with the guidance of existing toxicology model. Judged by the serum biochemical and histopathology result, it concluded that n-butanol layer of the ethanol extract of morning glory seed should be responsible for the nephrotoxity of this herb. The result indicated that this method could be an effective approach for the understanding and clinical diagnosis of traditional Chinese medicine induced nephrotoxicity.