2-酮基-3-脱氧辛酸(KDO)的合成研究

s the raw material, D-mannose was extended in the carbon chain by the Wittig reaction, turning to α,β-unsaturate octenoate. By β-elimination of the corresponding diol cyclic sulfite and the in situ trapping (DBU/ TMSCl) into enol silyl ether, it was moderatly converted to α-oxocarboxylic acid ester. With total eight steps yielding 36.3%, the synthesis of Ethyl 4,5:7,8-di-O-isopropylidene -3-deoxy-β-D-manno-2-octulopyranosonate was completed.