非酒精性脂肪肝检出率现状及其影响因素：基于北京市32万人群数据

BackgroundNon-alcoholic fatty liver disease has showed a high prevalence and a increasing trend especially towards younger age. It is of great public health significance to reduce damage through early detection of NAFLD in physical examination and intervention in time. ObjectiveTo investigate the detection rate of NAFLD in the Beijing physical examination population from 2018 to 2021and analyze its related influencing factors. MethodsPeople who received physical examinations at the Beijing Physical Examination Center from 2018-01-01 to 2021-12-31 were selected based on the inclusion criteriathe results of physical examinationlaboratory examinationand liver ultrasonography were collected for analysis. Univariate analysis was performed using t-testMann-Whitney U test and chi-square test. Multivariate Logistic regression was used to explore the influencing factors of NAFLD. ResultsA total 325 726 people were included in the studyof which 108 512 cases of NAFLD were detectedwith a detection rate of 33.31%. The results of liver ultrasonography revealed that the number of mildmoderate and severe NAFLD detections were 74 06233 281 and 1 169 casesaccounting for 68.25%30.67% and 1.08% of the detection populationrespectively. The detection rate of NAFLD was higher in males than females2 =17 518.893P<0.05. Chi-square test for trend revealed an age-dependent increase detection rate of NAFLD before 70 years oldand a subsequent decline after reaching 70 years old2 =14 397.61P<0.001. Higher detection rate was revealed in males than females among people aged 18-59 yearsP<0.05while lower detection rate in males than females among people aged 70 years oldP<0.05. Multivariate Logistic regression results showed that gendermaleOR=1.173aging30-39OR=1.60440-49OR=1.94850-59OR=2.48660-69OR=2.66370-79OR=2.079 80OR=1.149BMI18.5-23.9 kg/m2 OR=2.99724.0-27.9 kg/m2 OR=3.911 28.0 kg/m2 OR=11.780systolic blood pressure SBP 140 mmHgOR=1.200diastolic blood pressureDBP 90 mmHgOR=1.177fasting blood glucoseFBG 6.10 mmol/LOR=1.934triacylglycerolTG 1.70 mmol/LOR=2.946total cholesterolTC 5.20 mmol/LOR=1.050high-density lipoprotein cholesterol HDL-C420 mol/LUAfamale>360mol/LOR=2.067 were influencing factors for NAFLD P<0.001. ConclusionThe detection rate of NAFLD in physical examination population in Beijing was 33.31%the highest incidence showed in people aged 50 to 69 years. Malesoverweight and obese people are the high-risk groupsand abnormalities in blood lipidsblood pressure and blood glucose are also risk factors for NAFLD.