Serum levels of specialised pro-resolving molecule pathways are greatly increased in SARS-CoV-2 patients and correlate with markers of the adaptive immune response
Serum levels of specialised pro-resolving molecule pathways are greatly increased in SARS-CoV-2 patients and correlate with markers of the adaptive immune response
Abstract BackgroundSpecialised pro-resolution molecules (SPMs) halt the transition to chronic pathogenic inflammation. We aimed to quantify serum levels of pro- and anti-inflammatory bioactive lipids in SARS-CoV-2 patients, and to identify potential relationships with innate responses and clinical outcome. MethodsSerum from 50 hospital admitted inpatients (22 female, 28 male) with confirmed symptomatic SARS-CoV-2 infection and 94 age and sex matched cohort collected prior to the pandemic, were processed for quantification of bioactive lipids. Anti-nucleocapsid and anti-spike quantitative binding assays were performed. ResultsSARS-CoV-2 serum had significantly higher concentrations of omega-6 derived pro-inflammatory lipids and omega-6 and omega-3 derived SPMs, compared to age and sex matched controls. Levels of SPMs were not markedly altered by age. There were significant positive correlations between SPMs and other bioactive lipids and anti-spike antibody binding. Levels of some SPMs were significantly higher in patients with an anti-spike antibody value >0.5. Levels of linoleic acid (LA) and 5,6-dihydroxy-8Z,11Z,14Z-eicosatrienoic acid (5,6-DHET) were significantly lower in SARS-COV-2 patients who died. DiscussionSARS-COV-2 infection was associated with a robust activation of the pathways that generate the specialised pro-resolution molecules and other anti-inflammatory bioactive lipids, supporting the future investigation of these pathways which may inform the development of novel treatments.
Turnbull James、Jha Rakesh、Irving William L.、Chapman Victoria、Barrett David A.、Kim Dong-Hyun、Ortori Catherine A.、Lunt Eleanor、Gohir Sameer A.、Valdes Ana M.、Tarr Alexander W.、Tighe Patrick J.
NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust||Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham||School of Life Sciences, Faculty of Medicine and Health Sciences, The University of NottinghamNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust||Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of NottinghamNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust||School of Life Sciences, Faculty of Medicine and Health Sciences, The University of NottinghamNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust||School of Life Sciences, Faculty of Medicine and Health Sciences, The University of Nottingham||Pain Centre Versus Arthritis, University of NottinghamNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust||Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of NottinghamCentre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of NottinghamCentre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of NottinghamDepartment of Health Care for Older People (HCOP), Queen?ˉs Medical Centre, Nottingham University Hospitals NHS TrustNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust||Academic Rheumatology, University of NottinghamNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust||Pain Centre Versus Arthritis, University of Nottingham||Academic Rheumatology, University of NottinghamNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust||School of Life Sciences, Faculty of Medicine and Health Sciences, The University of NottinghamSchool of Life Sciences, Faculty of Medicine and Health Sciences, The University of Nottingham
医学研究方法基础医学生物科学研究方法、生物科学研究技术
SARS-CoV-2specialised pro-resolving moleculesimmune responsebioactive lipidsanti-nucleocapsid
Turnbull James,Jha Rakesh,Irving William L.,Chapman Victoria,Barrett David A.,Kim Dong-Hyun,Ortori Catherine A.,Lunt Eleanor,Gohir Sameer A.,Valdes Ana M.,Tarr Alexander W.,Tighe Patrick J..Serum levels of specialised pro-resolving molecule pathways are greatly increased in SARS-CoV-2 patients and correlate with markers of the adaptive immune response[EB/OL].(2025-03-28)[2025-05-14].https://www.medrxiv.org/content/10.1101/2021.12.07.21267409.点此复制
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