Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice
Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice
Abstract While health effects of conventional tobacco are well defined, data on vaping devices, including the most popular e-cigarette JUUL, are less established. Prior acute e-cigarette studies demonstrated inflammatory and cardiopulmonary physiology changes while chronic studies demonstrated extra-pulmonary effects, including neurotransmitter alterations in reward pathways. In this study we investigated effects of chronic flavored JUUL aerosol inhalation on inflammatory markers in brain, lung, heart, and colon. JUUL induced upregulation of cytokine and chemokine gene expression and increased HMGB1 and RAGE in the nucleus accumbens. Inflammatory gene expression increased in colon, and cardiopulmonary inflammatory responses to acute lung injury with lipopolysaccharide were exacerbated in the heart. Flavor-dependent changes in several responses were also observed. Our findings raise concerns regarding long-term risks of e-cigarette use as neuroinflammation may contribute to behavioral changes and mood disorders, while gut inflammation has been tied to poor systemic health and cardiac inflammation to development of heart disease. One Sentence SummaryChronic, daily inhalation of pod-based e-cigarette aerosols alters the inflammatory state across multiple organ systems in mice.
Moshensky Alex、Brand Cameron、Shin John、Mehta Sagar、Jahan Arya、Almarghalani Daniyah、Al-Kolla Rita、Shah Zahoor、Crotty Alexander Laura E.、Brown Joan Heller、Moon Hoyoung、Masso-Silva Jorge A.、Nilaad Sedtavut、Advani Ira、Pham Josephine、Park Kenneth、Byun Min、Gunge Deepti、Sari Youssef、Alhaddad Hasan、Sharma Aditi、Das Soumita、Perera Samantha
Pulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Department of Pharmacology, UCSDPulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Pulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Pulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of ToledoPulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of ToledoPulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Department of Pharmacology, UCSDDepartment of Pharmacology, UCSDPulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Pulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Pulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Pulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Pulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Pulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)||Division of Pulmonology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of MedicinePulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of ToledoDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of ToledoDepartment of Pathology, UCSDDepartment of Pathology, UCSDPulmonary and Critical Care Section, VA San Diego Healthcare System||Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego (UCSD)
基础医学药学生理学
JUULE-cigarettevapinginflammationlung complianceairway resistancenicotinetoxicology
Moshensky Alex,Brand Cameron,Shin John,Mehta Sagar,Jahan Arya,Almarghalani Daniyah,Al-Kolla Rita,Shah Zahoor,Crotty Alexander Laura E.,Brown Joan Heller,Moon Hoyoung,Masso-Silva Jorge A.,Nilaad Sedtavut,Advani Ira,Pham Josephine,Park Kenneth,Byun Min,Gunge Deepti,Sari Youssef,Alhaddad Hasan,Sharma Aditi,Das Soumita,Perera Samantha.Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice[EB/OL].(2025-03-28)[2025-05-21].https://www.biorxiv.org/content/10.1101/2021.03.09.434442.点此复制
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