3-（(2,4-二甲氧基苯基)（羟基）亚甲基）-1-异丙基吡咯烷-2，4-二酮合成的研究

In this paper, through comparison of the four routes for synthesis of 3-((2,4-dimethoxy phenyl)(hydroxy)methylene)-1-isopropyl-pyrrolidine-2,4-dione, 2,4-dimethoxybenzoic acid was selected as starting material. Firstly, it was transformed into 2,4-dimethoxybenzoate and then, at the presence of base, 2,4-dimethoxybenzoate was transformed into 2,4-dimethoxybenzoylacetate. Finally, 3-((2,4-dimethoxyphenyl) (hydroxy)methylene)-1-isopropyl-pyrrolidine-2,4-dione was prepared by reaction of 2,4-dimethoxybenzoylacetate with 2-isopropylaminoacetate. This procedure possess these features: cheap materials, operations simple, easy to control, stable yield. This work was also helpful to further application of the target compound.