枯草芽孢杆菌改善猪链球菌对Caco-2 细胞的破坏作用

In order to explore the antagonistic effect of Bacillus subtilis to Streptococcus suis infection, the antagonistic experiment was performed on Caco-2 cells to check the number of Streptococcus suis adhesion by bacteria count method. We also detected the paracellular permeability and the IL-8 secretion after Streptococcus suis infection or treated by Bacillus subtilis on Caco-2 cells. The results showed that Bacillus subtilis could reduced the number of Streptococcus suis adhesion to Caco-2 cells and the inflammatory cytokines IL-8 expression significantly. Thus, Bacillus subtilis could significantly improve the damaging effects of Streptococcus suis to Caco-2 cells, which provide a theoretical basis and experimental evidence for using Bacillus subtilis as a probiotic applications.