Potential cross-protection against SARS-CoV-2 from previous exposure to bovine coronavirus
Potential cross-protection against SARS-CoV-2 from previous exposure to bovine coronavirus
Abstract Humans have long shared infectious agents with cattle, and the common cold OC-43 CoV is a not-so-distant example of cross-species viral spillover. Human exposure to BCoV is certainly common, as the virus is endemic in cattle-raising regions. This article shows an in silico investigation of shared viral epitopes between BCoV and SARS-CoV-2. HLA recognition and lymphocyte reactivity were assessed using freely-available resources. Several epitopes were shared between BCoV and SARS-CoV-2, both for B and T lymphocytes. These data demonstrate that possible cross-protection is being induced by human exposure to cattle.
Querne Lana Bazan Peters、Beir?o Breno Castello Branco、Bastos Fernanda Zettel
Programa de P¨?s Gradua??o em Engenharia de Bioprocessos e Biotecnologia, Universidade Federal do Paran¨￠Departamento de Patologia B¨￠sica, Universidade Federal do Paran¨￠Programa de P¨?s Gradua??o em Engenharia de Bioprocessos e Biotecnologia, Universidade Federal do Paran¨￠
医学研究方法预防医学基础医学
bovine coronavirus (BCoV)epitopein silicoSARS-CoV-2
Querne Lana Bazan Peters,Beir?o Breno Castello Branco,Bastos Fernanda Zettel.Potential cross-protection against SARS-CoV-2 from previous exposure to bovine coronavirus[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2021.12.13.472476.点此复制
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