利用文本提取工具构建乳杆菌肽聚糖特异性免疫调节网络

IM : To investigate the mechanism that Lactobacillus peptidoglycan modulating mammal immune response. METHODS: BALB/c mice were administrated (i.p.) with Lactobacillus peptidoglcyan once or three times. Peritoneal macrophages and splenic lymphocytes were isolated for gene expression analysis using genechip. Medscan were used to building a specific immune modulating pathway based on published relating scientific papers. RESULTS: The pathway implied that PGN induced a pro-inflammatory response pathway mediated by TLR2 and NF-κb. However, the response was under subtle modulation by peptidoglycan reorganization proteins L and NOD2. CONCLUSIONS: Lactobacillus peptidoglycan induces a distinct immune response to maintain host immune homeostasis.