治疗干预下缺血性脑卒中静息态脑功能磁共振局部一致性的研究

Objective We detect the changes of brain regional homogeneity of the ischemic stroke patients before and after treatment，illustrating the possible mechanisms of stroke patients with limb functional recovery。Methods We do resting-state fMRI scan for 18 cases of ischemic stroke patients before and after treatment and 13 cases of normal control group ,and calculate regional homogeneity value of all local brain regions. We also assess the limb motor function of the patients before and after treatment（FMA score）, and use the statistical analysis method for the results compared between groups and statistical analysis.Results The FMA score of ischemic stroke patients before treatment are significantly higher than that before treatment.Comparing with the control group, cerebral region of increasing ReHo value in ischemic stroke patients before treatment is left middle temporal gyrus; cerebral regions of decreasing ReHo value are bilateral superior parietal lobule, medial occipital lobe, right inferior occipital lobe, left occipital lobe, left precuneus, orbital gyrus, etc.Comparing with the control group, cerebral regions of increasing ReHo value in ischemic stroke patients after treatment are lingual gyrus of left occipital lobe, fusiform gyrus of left temporal, left middle temporal lobe, pons, etc,Cerebral regions of decreasing ReHo value are located in the bilateral cerebellum,bilateral inferior temporal gyrus, etc.Conclusion Resting-state fMRI can be used to assess the functional recovery of ischemic stroke patients, further study the mechanism of functional recovery in stroke patients , and better guide the treatment of stroke.?????