yanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease
yanohydrin derivatives as enterovirus 71 (EV71) 3C protease (3C(pro)) inhibitors have been synthesized and assayed for their biochemical and antiviral activities. Compared with the reported inhibitors, cyanohydrins (1S,2S,2'S,5S)-16 and (1R,2S,2'S,5S)-16 exhibited significantly improved activity and attractive selectivity profiles against other proteases, which were a result of the specific interactions between the cyanohydrin moiety and the catalytic site of 3C(pro). Cyanohydrin as an anchoring group with high selectivity and excellent inhibitory activity represents a useful choice for cysteine protease inhibitors.
yanohydrin derivatives as enterovirus 71 (EV71) 3C protease (3C(pro)) inhibitors have been synthesized and assayed for their biochemical and antiviral activities. Compared with the reported inhibitors, cyanohydrins (1S,2S,2'S,5S)-16 and (1R,2S,2'S,5S)-16 exhibited significantly improved activity and attractive selectivity profiles against other proteases, which were a result of the specific interactions between the cyanohydrin moiety and the catalytic site of 3C(pro). Cyanohydrin as an anchoring group with high selectivity and excellent inhibitory activity represents a useful choice for cysteine protease inhibitors.
Sun, Qi、Li, Linfeng、Sun, Yuna、Li, Linfeng、Wang, Man、Zeng, Debin、Shang, Luqing、Lou, Zhiyong、Zhai, Yangyang、Wang, Yaxin、Wang, Yaxin、Sun, Qi、Yang, Xi、Yin, Zheng、Liu, Ying、Yang, Xi、Cui, Zhengjie、Lou, Zhiyong、Shang, Luqing、Shang, Luqing、Zhai, Yangyang、Liu, Ying、Zhao, Xiangshuai、Yin, Zheng、Zhao, Xiangshuai、Wang, Man、Wang, Man、Zeng, Debin、Lou, Zhiyong、Yang, Xi、Wang, Yaxin、Zhai, Yangyang、Cui, Zhengjie、Zeng, Debin、Li, Linfeng、Cui, Zhengjie、Yin, Zheng、Zhao, Xiangshuai、Liu, Ying
药学生物化学分子生物学
IDRUPINTRIVIRMYGDALINPRODUCTENZYMESESIGNELLS
Sun, Qi,Li, Linfeng,Sun, Yuna,Li, Linfeng,Wang, Man,Zeng, Debin,Shang, Luqing,Lou, Zhiyong,Zhai, Yangyang,Wang, Yaxin,Wang, Yaxin,Sun, Qi,Yang, Xi,Yin, Zheng,Liu, Ying,Yang, Xi,Cui, Zhengjie,Lou, Zhiyong,Shang, Luqing,Shang, Luqing,Zhai, Yangyang,Liu, Ying,Zhao, Xiangshuai,Yin, Zheng,Zhao, Xiangshuai,Wang, Man,Wang, Man,Zeng, Debin,Lou, Zhiyong,Yang, Xi,Wang, Yaxin,Zhai, Yangyang,Cui, Zhengjie,Zeng, Debin,Li, Linfeng,Cui, Zhengjie,Yin, Zheng,Zhao, Xiangshuai,Liu, Ying.yanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease[EB/OL].(2016-05-11)[2025-08-02].https://chinaxiv.org/abs/201605.01253.点此复制
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