吴茱萸内酯药理活性及其作用机制研究进展

Evodia lactone is a kind of volatile oil component derived from Evodia fructus, also known as cork lactone and limonin. It is a highly oxidized triterpenoid compound with a variety of health-promoting properties, Including anti-inflammatory, anti-oxidant, anti-bacterial, anti-insect, anti-virus, anti-mutagenic, analgesic and excellent anti-cancer activity, etc., and clinical trials have shown that its medication is safe and has broad prospects for drug development. However, limonin has problems such as strong rigid structure, poor water solubility, and low bioavailability, which have certain limitations on the study of its pharmacological effects and drug development. Therefore, how to use preparations or chemical means to improve its solubility and increase its bioavailability is of great significance for in-depth research and development of new limonin drugs. The author systematically summarized the mechanism of the pharmacological activity of limonin, and provided reference for further understanding of its pharmacological activity, development of therapeutic drugs and clinical application of limonin.