Limited immune responses after three months of BNT162b2 vaccine in SARS-CoV-2 uninfected elders living in long-term care facilities
Limited immune responses after three months of BNT162b2 vaccine in SARS-CoV-2 uninfected elders living in long-term care facilities
Abstract BackgroundSARS-CoV-2 vaccination is the most effective strategy to protect elders living in long-term care facilities (LTCF) against severe COVID-19, but primary vaccine responses are less effective in older adults. Here, we characterized the humoral responses following 3 months after mRNA/BNT162b2 vaccine in institutionalized elders. MethodsPlasma levels of specific SARS-CoV-2 total IgG, IgM and IgA antibodies were measured before and 3 months after vaccination in elders living in LTCF. Neutralization capacity was assessed in a pseudovirus neutralization assay against WH1 (original) and B.1.617.2/Delta variants. A group of younger adults was used as reference group. ResultsThree months after vaccination, uninfected-elders presented reduced specific SARS-CoV-2 IgG levels and significantly lower neutralization capacity against the WH1 and Delta virus compared to vaccinated uninfected younger individuals. In contrast, COVID-19 recovered elders showed significantly higher specific SARS-CoV-2 IgG levels after vaccination than younger counterparts, while showing similar neutralization activity against WH1 virus and increased neutralization capacity against Delta variant. Despite previously infected elders elicit potent cross-reactive immune responses similarly to younger individuals, higher quantities of specific SARS-CoV-2 IgG antibodies are required to reach the same neutralization levels. ConclusionsWhile hybrid immunity seems to be active in previously infected elders after three months from mRNA/BNT162b2 vaccination, humoral immune responses are diminished in COVID-19 uninfected vaccinated residents living in LTCF. These results suggests that a vaccine booster dose should be prioritized for this particularly vulnerable population. Word summaryWhile previously infected and vaccinated elders living in LTCF had comparable neutralizing antibody levels to younger individuals, vaccinated uninfected-residents showed limited neutralization capacity against both original and delta variants. Hybrid immunity seems to be active in elders and can be relevant to design vaccine boosting campaigns.
¨￠vila-Nieto Carlos、Font Marta、Palac¨an Dolors、Bonet-Sim¨? Josep Maria、Isnard Mar、Moreno Nemesio、Marfil Silvia、Toledo Ruth、Carrillo Jorge、Prat Nuria、Massanella Marta、Puig Teresa、Mateu Lourdes、Grau Eul¨¤lia、Trigueros Macedonia、Martinez Ana、Pradenas Edwards、Rovirosa Carla、Trinit¨| Benjamin、Blanco Juli¨¤、Ara Jordi、Clotet Bonaventura、Chamorro Anna
IrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol HospitalDirecci¨? d?ˉAtenci¨? Prim¨¤ria ¨C Metropolitana NordDirecci¨? d?ˉAtenci¨? Prim¨¤ria ¨C Metropolitana NordDirecci¨? d?ˉAtenci¨? Prim¨¤ria ¨C Metropolitana NordDirecci¨? d?ˉAtenci¨? Prim¨¤ria ¨C Metropolitana NordIrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol HospitalIrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)||Centro de Investigaci¨?n Biom¨|dica en Red de Enfermedades InfecciosasDirecci¨? d?ˉAtenci¨? Prim¨¤ria ¨C Metropolitana NordIrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)||Centro de Investigaci¨?n Biom¨|dica en Red de Enfermedades InfecciosasIrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital||University of Vic¨CCentral University of Catalonia (UVic-UCC)IrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)IrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol HospitalIrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)IrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)IrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)IrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)||Centro de Investigaci¨?n Biom¨|dica en Red de Enfermedades Infecciosas||University of Vic¨CCentral University of Catalonia (UVic-UCC)Germans Trias i Pujol Hospital and Universitat Aut¨°noma de BarcelonaIrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute (IGTP)||Direcci¨? d?ˉAtenci¨? Prim¨¤ria ¨C Metropolitana Nord||Centro de Investigaci¨?n Biom¨|dica en Red de Enfermedades Infecciosas||University of Vic¨CCentral University of Catalonia (UVic-UCC)Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital
预防医学医药卫生理论医学研究方法
SARS-CoV-2humoral immune responseLTCFNursing homesBNT162b2 vaccine
¨￠vila-Nieto Carlos,Font Marta,Palac¨an Dolors,Bonet-Sim¨? Josep Maria,Isnard Mar,Moreno Nemesio,Marfil Silvia,Toledo Ruth,Carrillo Jorge,Prat Nuria,Massanella Marta,Puig Teresa,Mateu Lourdes,Grau Eul¨¤lia,Trigueros Macedonia,Martinez Ana,Pradenas Edwards,Rovirosa Carla,Trinit¨| Benjamin,Blanco Juli¨¤,Ara Jordi,Clotet Bonaventura,Chamorro Anna.Limited immune responses after three months of BNT162b2 vaccine in SARS-CoV-2 uninfected elders living in long-term care facilities[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2021.11.18.21266502.点此复制
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